Which patients benefit from preoperative chemoradiotherapy for intermediate staged rectal cancer?

Won Sup Yoon, Won Park, Doo Ho Choi, Yong Chan Ahn, Ho Kyung Chun, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Won Ki Kang, Young Suk Park, Joon Oh Park, Ho Yeong Lim, Se Hoon Park, Jeeyun Lee

Research output: Contribution to journalArticle

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Abstract

Background: The aim of this study was to identify subgroups that benefit from preoperative or postoperative chemoradiotherapy (CRT) for rectal cancer of intermediate stage. Patients and Methods: Between 1999 and 2004, 118 and 177 patients matched with respect to clinical T stage, circumferential tumor extent (= 60% / > 60%), lymph node metastasis, and lymph node size (< 1 cm / = 1 cm), were allocated to preoperative CRT and postoperative CRT, respectively. In preoperative CRT, a total of 45 Gy was delivered with chemotherapy, and then surgery followed. In postoperative CRT, 45-51 Gy was delivered with chemotherapy following primary surgery. Results: Local recurrence, distant metastasis, disease-free survival, and disease-specific survival were not different between the two schemes. For a circumferential tumor extent of = 60%, local recurrence in preoperative CRT (3.6%) was lower than in postoperative CRT (11.9%) (p = 0.084, hazard ratio (HR) = 0.274, 95% confidence interval (CI) = 0.058-1.032). For a tumor located < 5cm from the anal verge, distant metastasis in preoperative CRT (18.9%) was lower than in postoperative CRT (34.4%) (p = 0.061, HR = 0.444, 95% CI = 0.188- 1.047), and 5-year disease-free survival rates in preoperative and postoperative CRT were 72.0 and 59.0%, respectively (p = 0.078). Conclusions: Our findings suggest that preoperative CRT might be appropriate in rectal cancer involving the limited circumferential lumen and located in the low rectum. However, further prospective studies are required.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalOnkologie
Volume34
Issue number1-2
DOIs
Publication statusPublished - 2011 Feb 1

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Chemoradiotherapy
Rectal Neoplasms
Neoplasm Metastasis
Disease-Free Survival
Lymph Nodes
Confidence Intervals
Recurrence
Drug Therapy
Neoplasms
Rectum
Survival Rate
Prospective Studies

Keywords

  • Postoperative chemoradiotherapy
  • Preoperative chemoradiotherapy
  • Rectal cancer

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Yoon, W. S., Park, W., Choi, D. H., Ahn, Y. C., Chun, H. K., Lee, W. Y., ... Lee, J. (2011). Which patients benefit from preoperative chemoradiotherapy for intermediate staged rectal cancer? Onkologie, 34(1-2), 36-41. https://doi.org/10.1159/000323382

Which patients benefit from preoperative chemoradiotherapy for intermediate staged rectal cancer? / Yoon, Won Sup; Park, Won; Choi, Doo Ho; Ahn, Yong Chan; Chun, Ho Kyung; Lee, Woo Yong; Yun, Seong Hyeon; Kim, Hee Cheol; Cho, Yong Beom; Kang, Won Ki; Park, Young Suk; Park, Joon Oh; Lim, Ho Yeong; Park, Se Hoon; Lee, Jeeyun.

In: Onkologie, Vol. 34, No. 1-2, 01.02.2011, p. 36-41.

Research output: Contribution to journalArticle

Yoon, WS, Park, W, Choi, DH, Ahn, YC, Chun, HK, Lee, WY, Yun, SH, Kim, HC, Cho, YB, Kang, WK, Park, YS, Park, JO, Lim, HY, Park, SH & Lee, J 2011, 'Which patients benefit from preoperative chemoradiotherapy for intermediate staged rectal cancer?', Onkologie, vol. 34, no. 1-2, pp. 36-41. https://doi.org/10.1159/000323382
Yoon, Won Sup ; Park, Won ; Choi, Doo Ho ; Ahn, Yong Chan ; Chun, Ho Kyung ; Lee, Woo Yong ; Yun, Seong Hyeon ; Kim, Hee Cheol ; Cho, Yong Beom ; Kang, Won Ki ; Park, Young Suk ; Park, Joon Oh ; Lim, Ho Yeong ; Park, Se Hoon ; Lee, Jeeyun. / Which patients benefit from preoperative chemoradiotherapy for intermediate staged rectal cancer?. In: Onkologie. 2011 ; Vol. 34, No. 1-2. pp. 36-41.
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abstract = "Background: The aim of this study was to identify subgroups that benefit from preoperative or postoperative chemoradiotherapy (CRT) for rectal cancer of intermediate stage. Patients and Methods: Between 1999 and 2004, 118 and 177 patients matched with respect to clinical T stage, circumferential tumor extent (= 60{\%} / > 60{\%}), lymph node metastasis, and lymph node size (< 1 cm / = 1 cm), were allocated to preoperative CRT and postoperative CRT, respectively. In preoperative CRT, a total of 45 Gy was delivered with chemotherapy, and then surgery followed. In postoperative CRT, 45-51 Gy was delivered with chemotherapy following primary surgery. Results: Local recurrence, distant metastasis, disease-free survival, and disease-specific survival were not different between the two schemes. For a circumferential tumor extent of = 60{\%}, local recurrence in preoperative CRT (3.6{\%}) was lower than in postoperative CRT (11.9{\%}) (p = 0.084, hazard ratio (HR) = 0.274, 95{\%} confidence interval (CI) = 0.058-1.032). For a tumor located < 5cm from the anal verge, distant metastasis in preoperative CRT (18.9{\%}) was lower than in postoperative CRT (34.4{\%}) (p = 0.061, HR = 0.444, 95{\%} CI = 0.188- 1.047), and 5-year disease-free survival rates in preoperative and postoperative CRT were 72.0 and 59.0{\%}, respectively (p = 0.078). Conclusions: Our findings suggest that preoperative CRT might be appropriate in rectal cancer involving the limited circumferential lumen and located in the low rectum. However, further prospective studies are required.",
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AU - Yoon, Won Sup

AU - Park, Won

AU - Choi, Doo Ho

AU - Ahn, Yong Chan

AU - Chun, Ho Kyung

AU - Lee, Woo Yong

AU - Yun, Seong Hyeon

AU - Kim, Hee Cheol

AU - Cho, Yong Beom

AU - Kang, Won Ki

AU - Park, Young Suk

AU - Park, Joon Oh

AU - Lim, Ho Yeong

AU - Park, Se Hoon

AU - Lee, Jeeyun

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N2 - Background: The aim of this study was to identify subgroups that benefit from preoperative or postoperative chemoradiotherapy (CRT) for rectal cancer of intermediate stage. Patients and Methods: Between 1999 and 2004, 118 and 177 patients matched with respect to clinical T stage, circumferential tumor extent (= 60% / > 60%), lymph node metastasis, and lymph node size (< 1 cm / = 1 cm), were allocated to preoperative CRT and postoperative CRT, respectively. In preoperative CRT, a total of 45 Gy was delivered with chemotherapy, and then surgery followed. In postoperative CRT, 45-51 Gy was delivered with chemotherapy following primary surgery. Results: Local recurrence, distant metastasis, disease-free survival, and disease-specific survival were not different between the two schemes. For a circumferential tumor extent of = 60%, local recurrence in preoperative CRT (3.6%) was lower than in postoperative CRT (11.9%) (p = 0.084, hazard ratio (HR) = 0.274, 95% confidence interval (CI) = 0.058-1.032). For a tumor located < 5cm from the anal verge, distant metastasis in preoperative CRT (18.9%) was lower than in postoperative CRT (34.4%) (p = 0.061, HR = 0.444, 95% CI = 0.188- 1.047), and 5-year disease-free survival rates in preoperative and postoperative CRT were 72.0 and 59.0%, respectively (p = 0.078). Conclusions: Our findings suggest that preoperative CRT might be appropriate in rectal cancer involving the limited circumferential lumen and located in the low rectum. However, further prospective studies are required.

AB - Background: The aim of this study was to identify subgroups that benefit from preoperative or postoperative chemoradiotherapy (CRT) for rectal cancer of intermediate stage. Patients and Methods: Between 1999 and 2004, 118 and 177 patients matched with respect to clinical T stage, circumferential tumor extent (= 60% / > 60%), lymph node metastasis, and lymph node size (< 1 cm / = 1 cm), were allocated to preoperative CRT and postoperative CRT, respectively. In preoperative CRT, a total of 45 Gy was delivered with chemotherapy, and then surgery followed. In postoperative CRT, 45-51 Gy was delivered with chemotherapy following primary surgery. Results: Local recurrence, distant metastasis, disease-free survival, and disease-specific survival were not different between the two schemes. For a circumferential tumor extent of = 60%, local recurrence in preoperative CRT (3.6%) was lower than in postoperative CRT (11.9%) (p = 0.084, hazard ratio (HR) = 0.274, 95% confidence interval (CI) = 0.058-1.032). For a tumor located < 5cm from the anal verge, distant metastasis in preoperative CRT (18.9%) was lower than in postoperative CRT (34.4%) (p = 0.061, HR = 0.444, 95% CI = 0.188- 1.047), and 5-year disease-free survival rates in preoperative and postoperative CRT were 72.0 and 59.0%, respectively (p = 0.078). Conclusions: Our findings suggest that preoperative CRT might be appropriate in rectal cancer involving the limited circumferential lumen and located in the low rectum. However, further prospective studies are required.

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KW - Preoperative chemoradiotherapy

KW - Rectal cancer

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