White matter lesions and poor outcome after intracerebral hemorrhage: A nationwide cohort study

S. H. Lee, B. J. Kim, W. S. Ryu, Chi Kyung Kim, N. Kim, B. J. Park, B. W. Yoon

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Abstract

BACKGROUND: The ability to predict poor outcome is important for patient care and treatment decision-making in cases of intracerebral hemorrhage (ICH). Previous studies have included relatively brief follow-up periods and small numbers of patients, and are limited in terms of considerations regarding individual brain vulnerabilities. METHODS: The authors prospectively enrolled 1,321 ICH patients nationwide from 33 hospitals. Clinical, laboratory, and imaging variables, including white matter lesions (WMLs), were collected at admission. Immediate outcome after ICH was measured using total Glasgow Coma Scale (GCS) score at admission, early outcome using 30-day mortality, and long-term outcome using relative risk for mortality. The vital status of included patients was ascertained on December 31, 2006, using Korean National Death Certificates (mean follow-up, 32.6 months). RESULTS: Of the 1,321 ICH patients included, 352 (27.8%) presented with a moderate GCS score (8.5-12.4) and 249 (19.7%) with a severe GCS score (≤8.4). The mortality rate was 9.1% at day 30 post-ICH and 381 patients (29.8%) had died up to the end of December 2006. Extensive WMLs were associated with severe GCS scores at admission (odds ratio [OR] 2.45, 95% confidence interval [CI] 1.73-3.46), 30-day mortality (OR 2.52, 95% CI 1.33-4.75), and the relative risk for mortality (RR 2.61, 95% CI 1.79-3.82) after adjusting for relevant covariates. CONCLUSIONS: These findings suggest that white matter lesions, which may reflect the vulnerability of individual brains to pathologic insults, should be considered when assessing immediate, early, and long-term outcomes after intracerebral hemorrhage.

Original languageEnglish
Pages (from-to)1502-1510
Number of pages9
JournalNeurology
Volume74
Issue number19
DOIs
Publication statusPublished - 2010 May 11
Externally publishedYes

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Cerebral Hemorrhage
Glasgow Coma Scale
Cohort Studies
Mortality
Confidence Intervals
Odds Ratio
Aptitude
Death Certificates
Brain
White Matter
Decision Making
Patient Care

ASJC Scopus subject areas

  • Clinical Neurology

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White matter lesions and poor outcome after intracerebral hemorrhage : A nationwide cohort study. / Lee, S. H.; Kim, B. J.; Ryu, W. S.; Kim, Chi Kyung; Kim, N.; Park, B. J.; Yoon, B. W.

In: Neurology, Vol. 74, No. 19, 11.05.2010, p. 1502-1510.

Research output: Contribution to journalArticle

Lee, S. H. ; Kim, B. J. ; Ryu, W. S. ; Kim, Chi Kyung ; Kim, N. ; Park, B. J. ; Yoon, B. W. / White matter lesions and poor outcome after intracerebral hemorrhage : A nationwide cohort study. In: Neurology. 2010 ; Vol. 74, No. 19. pp. 1502-1510.
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