Whole genome sequencing in psychiatric disorders: The WGSPD consortium

Stephan J. Sanders, Benjamin M. Neale, Hailiang Huang, Donna M. Werling, Joon-Yong An, Shan Dong, Goncalo Abecasis, P. Alexander Arguello, John Blangero, Michael Boehnke, Mark J. Daly, Kevin Eggan, Daniel H. Geschwind, David C. Glahn, David B. Goldstein, Raquel E. Gur, Robert E. Handsaker, Steven A. McCarroll, Roel A. Ophoff, Aarno PalotieCarlos N. Pato, Chiara Sabatti, Matthew W. State, A. Jeremy Willsey, Steven E. Hyman, Anjene M. Addington, Thomas Lehner, Nelson B. Freimer

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

As technology advances, whole genome sequencing (WGS) is likely to supersede other genotyping technologies. The rate of this change depends on its relative cost and utility. Variants identified uniquely through WGS may reveal novel biological pathways underlying complex disorders and provide high-resolution insight into when, where, and in which cell type these pathways are affected. Alternatively, cheaper and less computationally intensive approaches may yield equivalent insights. Understanding the role of rare variants in the noncoding gene-regulating genome through pilot WGS projects will be critical to determining which of these two extremes best represents reality. With large cohorts, well-defined risk loci, and a compelling need to understand the underlying biology, psychiatric disorders have a role to play in this preliminary WGS assessment. The Whole Genome Sequencing for Psychiatric Disorders Consortium will integrate data for 18,000 individuals with psychiatric disorders, beginning with autism spectrum disorder, schizophrenia, bipolar disorder, and major depressive disorder, along with over 150,000 controls.

Original languageEnglish
Pages (from-to)1661-1668
Number of pages8
JournalNature Neuroscience
Volume20
Issue number12
DOIs
Publication statusPublished - 2017 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Sanders, S. J., Neale, B. M., Huang, H., Werling, D. M., An, J-Y., Dong, S., Abecasis, G., Arguello, P. A., Blangero, J., Boehnke, M., Daly, M. J., Eggan, K., Geschwind, D. H., Glahn, D. C., Goldstein, D. B., Gur, R. E., Handsaker, R. E., McCarroll, S. A., Ophoff, R. A., ... Freimer, N. B. (2017). Whole genome sequencing in psychiatric disorders: The WGSPD consortium. Nature Neuroscience, 20(12), 1661-1668. https://doi.org/10.1038/s41593-017-0017-9