Why serological responses during cystitis are limited

Hae Woong Choi, Soman N. Abraham

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

The high frequency of urinary tract infections (UTIs), some of which appear to be endogenous relapses rather than reinfections by new isolates, point to defects in the host’s memory immune response. It has been known for many decades that, whereas kidney infections evoked an antibody response to the infecting bacteria, infections limited to the bladder failed to do so. We have identified the existence of a broadly immunosuppressive transcriptional program associated with the bladder, but not the kidneys, during infection of the urinary tract that is dependent on bladder mast cells. This involves the localized secretion of IL-10 and results in the suppression of humoral immune responses in the bladder. Mast cell-mediated immune suppression could suggest a role for these cells in critically balancing the needs to clear infections with the imperative to prevent harmful immune reactions in the host.

Original languageEnglish
Article number19
JournalPathogens
Volume5
Issue number1
DOIs
Publication statusPublished - 2016 Mar 1
Externally publishedYes

Keywords

  • Cystitis
  • Defects in memory response
  • Mast cells
  • Recurrent UTI
  • Serology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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