Abstract
A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 585-593 |
| Number of pages | 9 |
| Journal | Bioorganic Chemistry |
| Volume | 87 |
| DOIs | |
| Publication status | Published - 2019 Jun 1 |
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Keywords
- iNOS
- Molecular docking
- NO inhibitors
- Physalis peruviana
- Withanolides
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Drug Discovery
- Organic Chemistry
Cite this
Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS. / Dong, Bangjian; An, Lijun; Yang, Xueyuan; Zhang, Xuke; Zhang, Jie; Tuerhong, Muhetaer; Jin, Da Qing; Ohizumi, Yasushi; Lee, Dongho; Xu, Jing; Guo, Yuanqiang.
In: Bioorganic Chemistry, Vol. 87, 01.06.2019, p. 585-593.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS
AU - Dong, Bangjian
AU - An, Lijun
AU - Yang, Xueyuan
AU - Zhang, Xuke
AU - Zhang, Jie
AU - Tuerhong, Muhetaer
AU - Jin, Da Qing
AU - Ohizumi, Yasushi
AU - Lee, Dongho
AU - Xu, Jing
AU - Guo, Yuanqiang
PY - 2019/6/1
Y1 - 2019/6/1
N2 - A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.
AB - A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.
KW - iNOS
KW - Molecular docking
KW - NO inhibitors
KW - Physalis peruviana
KW - Withanolides
UR - http://www.scopus.com/inward/record.url?scp=85063457623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063457623&partnerID=8YFLogxK
U2 - 10.1016/j.bioorg.2019.03.051
DO - 10.1016/j.bioorg.2019.03.051
M3 - Article
C2 - 30928880
AN - SCOPUS:85063457623
VL - 87
SP - 585
EP - 593
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
SN - 0045-2068
ER -