Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

Bangjian Dong; Lijun An; Xueyuan Yang; Xuke Zhang; Jie Zhang; Muhetaer Tuerhong; Da Qing Jin; Yasushi Ohizumi; Dongho Lee; Jing Xu; Yuanqiang Guo

doi:10.1016/j.bioorg.2019.03.051

Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

Bangjian Dong, Lijun An, Xueyuan Yang, Xuke Zhang, Jie Zhang, Muhetaer Tuerhong, Da Qing Jin, Yasushi Ohizumi, Dongho Lee, Jing Xu, Yuanqiang Guo

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.

Original language	English
Pages (from-to)	585-593
Number of pages	9
Journal	Bioorganic Chemistry
Volume	87
DOIs	https://doi.org/10.1016/j.bioorg.2019.03.051
Publication status	Published - 2019 Jun

Keywords

Molecular docking
NO inhibitors
Physalis peruviana
Withanolides
iNOS

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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10.1016/j.bioorg.2019.03.051

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@article{ad656c3822f74340bf76be3a39a89437,

title = "Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS",

abstract = "A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.",

keywords = "Molecular docking, NO inhibitors, Physalis peruviana, Withanolides, iNOS",

author = "Bangjian Dong and Lijun An and Xueyuan Yang and Xuke Zhang and Jie Zhang and Muhetaer Tuerhong and Jin, {Da Qing} and Yasushi Ohizumi and Dongho Lee and Jing Xu and Yuanqiang Guo",

note = "Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 , 21642016 , and 21372125 ), the National Key Research and Development Program of China (No. 2018YFA0507204 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), the Hundred Young Academic Leaders Program of Nankai University , and State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources ( Guangxi Normal University , No. CMEMR2018-B02 ). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jun,

doi = "10.1016/j.bioorg.2019.03.051",

language = "English",

volume = "87",

pages = "585--593",

journal = "Bioorganic Chemistry",

issn = "0045-2068",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

AU - Dong, Bangjian

AU - An, Lijun

AU - Yang, Xueyuan

AU - Zhang, Xuke

AU - Zhang, Jie

AU - Tuerhong, Muhetaer

AU - Jin, Da Qing

AU - Ohizumi, Yasushi

AU - Lee, Dongho

AU - Xu, Jing

AU - Guo, Yuanqiang

N1 - Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 , 21642016 , and 21372125 ), the National Key Research and Development Program of China (No. 2018YFA0507204 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), the Hundred Young Academic Leaders Program of Nankai University , and State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources ( Guangxi Normal University , No. CMEMR2018-B02 ). Publisher Copyright: © 2019 Elsevier Inc.

PY - 2019/6

Y1 - 2019/6

N2 - A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.

AB - A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.

KW - Molecular docking

KW - NO inhibitors

KW - Physalis peruviana

KW - Withanolides

KW - iNOS

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DO - 10.1016/j.bioorg.2019.03.051

M3 - Article

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AN - SCOPUS:85063457623

SN - 0045-2068

VL - 87

SP - 585

EP - 593

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

ER -

Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

Abstract

Keywords

ASJC Scopus subject areas

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