Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

Bangjian Dong; Lijun An; Xueyuan Yang; Xuke Zhang; Jie Zhang; Muhetaer Tuerhong; Da Qing Jin; Yasushi Ohizumi; Dongho Lee; Jing Xu; Yuanqiang Guo

doi:10.1016/j.bioorg.2019.03.051

Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

Bangjian Dong, Lijun An, Xueyuan Yang, Xuke Zhang, Jie Zhang, Muhetaer Tuerhong, Da Qing Jin, Yasushi Ohizumi, Dongho Lee, Jing Xu, Yuanqiang Guo

Division of Biotechnology

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.

Original language	English
Pages (from-to)	585-593
Number of pages	9
Journal	Bioorganic Chemistry
Volume	87
DOIs	https://doi.org/10.1016/j.bioorg.2019.03.051
Publication status	Published - 2019 Jun 1

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Keywords

iNOS
Molecular docking
NO inhibitors
Physalis peruviana
Withanolides

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

Cite this

Dong, B., An, L., Yang, X., Zhang, X., Zhang, J., Tuerhong, M., Jin, D. Q., Ohizumi, Y., Lee, D., Xu, J., & Guo, Y. (2019). Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS. Bioorganic Chemistry, 87, 585-593. https://doi.org/10.1016/j.bioorg.2019.03.051

Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS. / Dong, Bangjian; An, Lijun; Yang, Xueyuan; Zhang, Xuke; Zhang, Jie; Tuerhong, Muhetaer; Jin, Da Qing; Ohizumi, Yasushi; Lee, Dongho; Xu, Jing; Guo, Yuanqiang.

In: Bioorganic Chemistry, Vol. 87, 01.06.2019, p. 585-593.

Research output: Contribution to journal › Article

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abstract = "A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.",

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author = "Bangjian Dong and Lijun An and Xueyuan Yang and Xuke Zhang and Jie Zhang and Muhetaer Tuerhong and Jin, {Da Qing} and Yasushi Ohizumi and Dongho Lee and Jing Xu and Yuanqiang Guo",

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AU - Tuerhong, Muhetaer

AU - Jin, Da Qing

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10.1016/j.bioorg.2019.03.051