@article{ad656c3822f74340bf76be3a39a89437,
title = "Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS",
abstract = "A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.",
keywords = "Molecular docking, NO inhibitors, Physalis peruviana, Withanolides, iNOS",
author = "Bangjian Dong and Lijun An and Xueyuan Yang and Xuke Zhang and Jie Zhang and Muhetaer Tuerhong and Jin, {Da Qing} and Yasushi Ohizumi and Dongho Lee and Jing Xu and Yuanqiang Guo",
note = "Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 , 21642016 , and 21372125 ), the National Key Research and Development Program of China (No. 2018YFA0507204 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), the Hundred Young Academic Leaders Program of Nankai University , and State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources ( Guangxi Normal University , No. CMEMR2018-B02 ). Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107, 21642016, and 21372125), the National Key Research and Development Program of China (No. 2018YFA0507204), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), the Hundred Young Academic Leaders Program of Nankai University, and State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2018-B02).",
year = "2019",
month = jun,
doi = "10.1016/j.bioorg.2019.03.051",
language = "English",
volume = "87",
pages = "585--593",
journal = "Bioorganic Chemistry",
issn = "0045-2068",
publisher = "Academic Press Inc.",
}