Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

Bangjian Dong, Lijun An, Xueyuan Yang, Xuke Zhang, Jie Zhang, Muhetaer Tuerhong, Da Qing Jin, Yasushi Ohizumi, Dongho Lee, Jing Xu, Yuanqiang Guo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.

Original languageEnglish
Pages (from-to)585-593
Number of pages9
JournalBioorganic Chemistry
Volume87
DOIs
Publication statusPublished - 2019 Jun 1

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Keywords

  • iNOS
  • Molecular docking
  • NO inhibitors
  • Physalis peruviana
  • Withanolides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

Cite this

Dong, B., An, L., Yang, X., Zhang, X., Zhang, J., Tuerhong, M., Jin, D. Q., Ohizumi, Y., Lee, D., Xu, J., & Guo, Y. (2019). Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS. Bioorganic Chemistry, 87, 585-593. https://doi.org/10.1016/j.bioorg.2019.03.051