Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways

R. K. Seong, J. A. Kim, Ok Shin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Wogonin, a flavonoid isolated from Scutellaria baicalensis, has attracted increasing scientific attention in recent years because of its potent anti-tumor activity. Its role during viral infection has largely been unexplored. Wogonin treatment effectively suppressed both influenza A and B virus replication in Madin-Darby Canine Kidney (MDCK) cells and human lung epithelial (A549) cells. In contrast, wogonin treatment following influenza A virus infection led to up-regulation of interferon (IFN)-induced antiviral signaling. Additionally, influenza A virus infection in A549 cells induced 5' adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and activation in a time-dependent manner and wogonin treatment led to the suppression of AMPK phosphorylation. Furthermore, the treatment with AMPK-specific inhibitor (compound C; CC) attenuated influenza A virus replication. These data suggest that wogonin possesses a potent anti-influenza activity mediated by regulation of AMPK activation, suggesting that wogonin has the potential to be developed as an anti-influenza drug.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalActa Virologica
Volume62
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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Scutellaria baicalensis
Adenosine Monophosphate
Flavonoids
Protein Kinases
Human Influenza
Influenza A virus
Virus Diseases
Infection
Virus Replication
Phosphorylation
Influenza B virus
Madin Darby Canine Kidney Cells
Protein Kinase Inhibitors
Interferons
Antiviral Agents
wogonin
Up-Regulation
Epithelial Cells
Lung
Pharmaceutical Preparations

Keywords

  • AMPK
  • Anti-viral signaling
  • Influenza
  • Interferon
  • Wogonin

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways. / Seong, R. K.; Kim, J. A.; Shin, Ok.

In: Acta Virologica, Vol. 62, No. 1, 01.01.2018, p. 78-85.

Research output: Contribution to journalArticle

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