Women with threatened preterm labour followed by term delivery have an increased risk of spontaneous preterm birth in subsequent pregnancies

a population-based cohort study

Geum-Joon Cho, S. J. Choi, K. M. Lee, Sung Won Han, H. Y. Kim, K. H. Ahn, Soon Cheol Hong, Hai Joong Kim, Min Jeong Oh

Research output: Contribution to journalArticle

Abstract

Objectives: To evaluate the association of a history of threatened preterm labour (TPL) followed by term delivery with the risk of spontaneous preterm delivery (PTD) in subsequent pregnancy. Design: Population-based cohort study. Setting: Data of the National Health Insurance Claims Database and a national health-screening programme for infants and children in South Korea. Population: Women who had their first singleton delivery in 2010 and a subsequent second singleton delivery between 2011 and 2015. Methods: Multivariable analysis adjusting for maternal age and interval between first and second deliveries was used to assess the risk of PTD based on PTD, TPL followed by term delivery, and term delivery in the first pregnancy. Main outcome measures: The risk of PTD during the second pregnancy. Results: This study included 115 629 women with two consecutive deliveries during the study period. Spontaneous PTD rates in the second pregnancy were 7.71, 2.22 and 1.02% in women with PTD, TPL followed by term delivery, and term delivery in the first pregnancy, respectively. Threatened preterm labour followed by term delivery in the first pregnancy was associated with increased risk of PTD in the subsequent pregnancy after adjustment for potential confounding factors (adjusted odds ratio 2.21; 95% CI 1.76–2.78). Conclusion: Although women with a history of TPL followed by term delivery had a lower risk of PTD during a subsequent pregnancy compared with those with history of previous PTD, they still had a significantly increased risk of PTD compared with those who delivered at term without TPL. Tweetable abstract: The history of threatened preterm labour followed by term delivery is related to increased risk of subsequent spontaneous preterm delivery.

Original languageEnglish
JournalBJOG: An International Journal of Obstetrics and Gynaecology
DOIs
Publication statusPublished - 2019 Jan 1

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Premature Obstetric Labor
Premature Birth
Cohort Studies
Pregnancy
Population
National Health Programs
Republic of Korea
Maternal Age
History
Odds Ratio
Outcome Assessment (Health Care)
Databases

Keywords

  • Preterm delivery
  • recurrence
  • threatened preterm labour

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

@article{4360b3729c2b4d8cb21d2c55377c0459,
title = "Women with threatened preterm labour followed by term delivery have an increased risk of spontaneous preterm birth in subsequent pregnancies: a population-based cohort study",
abstract = "Objectives: To evaluate the association of a history of threatened preterm labour (TPL) followed by term delivery with the risk of spontaneous preterm delivery (PTD) in subsequent pregnancy. Design: Population-based cohort study. Setting: Data of the National Health Insurance Claims Database and a national health-screening programme for infants and children in South Korea. Population: Women who had their first singleton delivery in 2010 and a subsequent second singleton delivery between 2011 and 2015. Methods: Multivariable analysis adjusting for maternal age and interval between first and second deliveries was used to assess the risk of PTD based on PTD, TPL followed by term delivery, and term delivery in the first pregnancy. Main outcome measures: The risk of PTD during the second pregnancy. Results: This study included 115 629 women with two consecutive deliveries during the study period. Spontaneous PTD rates in the second pregnancy were 7.71, 2.22 and 1.02{\%} in women with PTD, TPL followed by term delivery, and term delivery in the first pregnancy, respectively. Threatened preterm labour followed by term delivery in the first pregnancy was associated with increased risk of PTD in the subsequent pregnancy after adjustment for potential confounding factors (adjusted odds ratio 2.21; 95{\%} CI 1.76–2.78). Conclusion: Although women with a history of TPL followed by term delivery had a lower risk of PTD during a subsequent pregnancy compared with those with history of previous PTD, they still had a significantly increased risk of PTD compared with those who delivered at term without TPL. Tweetable abstract: The history of threatened preterm labour followed by term delivery is related to increased risk of subsequent spontaneous preterm delivery.",
keywords = "Preterm delivery, recurrence, threatened preterm labour",
author = "Geum-Joon Cho and Choi, {S. J.} and Lee, {K. M.} and Han, {Sung Won} and Kim, {H. Y.} and Ahn, {K. H.} and Hong, {Soon Cheol} and Kim, {Hai Joong} and Oh, {Min Jeong}",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/1471-0528.15653",
language = "English",
journal = "BJOG: An International Journal of Obstetrics and Gynaecology",
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TY - JOUR

T1 - Women with threatened preterm labour followed by term delivery have an increased risk of spontaneous preterm birth in subsequent pregnancies

T2 - a population-based cohort study

AU - Cho, Geum-Joon

AU - Choi, S. J.

AU - Lee, K. M.

AU - Han, Sung Won

AU - Kim, H. Y.

AU - Ahn, K. H.

AU - Hong, Soon Cheol

AU - Kim, Hai Joong

AU - Oh, Min Jeong

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: To evaluate the association of a history of threatened preterm labour (TPL) followed by term delivery with the risk of spontaneous preterm delivery (PTD) in subsequent pregnancy. Design: Population-based cohort study. Setting: Data of the National Health Insurance Claims Database and a national health-screening programme for infants and children in South Korea. Population: Women who had their first singleton delivery in 2010 and a subsequent second singleton delivery between 2011 and 2015. Methods: Multivariable analysis adjusting for maternal age and interval between first and second deliveries was used to assess the risk of PTD based on PTD, TPL followed by term delivery, and term delivery in the first pregnancy. Main outcome measures: The risk of PTD during the second pregnancy. Results: This study included 115 629 women with two consecutive deliveries during the study period. Spontaneous PTD rates in the second pregnancy were 7.71, 2.22 and 1.02% in women with PTD, TPL followed by term delivery, and term delivery in the first pregnancy, respectively. Threatened preterm labour followed by term delivery in the first pregnancy was associated with increased risk of PTD in the subsequent pregnancy after adjustment for potential confounding factors (adjusted odds ratio 2.21; 95% CI 1.76–2.78). Conclusion: Although women with a history of TPL followed by term delivery had a lower risk of PTD during a subsequent pregnancy compared with those with history of previous PTD, they still had a significantly increased risk of PTD compared with those who delivered at term without TPL. Tweetable abstract: The history of threatened preterm labour followed by term delivery is related to increased risk of subsequent spontaneous preterm delivery.

AB - Objectives: To evaluate the association of a history of threatened preterm labour (TPL) followed by term delivery with the risk of spontaneous preterm delivery (PTD) in subsequent pregnancy. Design: Population-based cohort study. Setting: Data of the National Health Insurance Claims Database and a national health-screening programme for infants and children in South Korea. Population: Women who had their first singleton delivery in 2010 and a subsequent second singleton delivery between 2011 and 2015. Methods: Multivariable analysis adjusting for maternal age and interval between first and second deliveries was used to assess the risk of PTD based on PTD, TPL followed by term delivery, and term delivery in the first pregnancy. Main outcome measures: The risk of PTD during the second pregnancy. Results: This study included 115 629 women with two consecutive deliveries during the study period. Spontaneous PTD rates in the second pregnancy were 7.71, 2.22 and 1.02% in women with PTD, TPL followed by term delivery, and term delivery in the first pregnancy, respectively. Threatened preterm labour followed by term delivery in the first pregnancy was associated with increased risk of PTD in the subsequent pregnancy after adjustment for potential confounding factors (adjusted odds ratio 2.21; 95% CI 1.76–2.78). Conclusion: Although women with a history of TPL followed by term delivery had a lower risk of PTD during a subsequent pregnancy compared with those with history of previous PTD, they still had a significantly increased risk of PTD compared with those who delivered at term without TPL. Tweetable abstract: The history of threatened preterm labour followed by term delivery is related to increased risk of subsequent spontaneous preterm delivery.

KW - Preterm delivery

KW - recurrence

KW - threatened preterm labour

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DO - 10.1111/1471-0528.15653

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JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

ER -