Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis

Tae Hoon Lee, Sung Eun Kim, Jae Yong Lee, Jae Gyoon Kim, Kyeongsoon Park, Hak Jun Kim

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.

    Original languageEnglish
    Pages (from-to)152-161
    Number of pages10
    JournalJournal of Industrial and Engineering Chemistry
    Volume73
    DOIs
    Publication statusPublished - 2019 May 25

    Keywords

    • Achilles tendinitis
    • Diclofenac
    • Fibrous sheet
    • Polycaprolactone
    • Tendon healing

    ASJC Scopus subject areas

    • Chemical Engineering(all)

    Fingerprint

    Dive into the research topics of 'Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis'. Together they form a unique fingerprint.

    Cite this