Abstract
We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.
Original language | English |
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Pages (from-to) | 152-161 |
Number of pages | 10 |
Journal | Journal of Industrial and Engineering Chemistry |
Volume | 73 |
DOIs | |
Publication status | Published - 2019 May 25 |
Keywords
- Achilles tendinitis
- Diclofenac
- Fibrous sheet
- Polycaprolactone
- Tendon healing
ASJC Scopus subject areas
- Chemical Engineering(all)