Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis

Tae Hoon Lee, Sung Eun Kim, Jae Yong Lee, Jae Gyoon Kim, Kyeongsoon Park, Hak Jun Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.

Original languageEnglish
JournalJournal of Industrial and Engineering Chemistry
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Polycaprolactone
Diclofenac
Tendons
Collagenases
Tissue
Collagen
Anti-Inflammatory Agents
Interleukin-13
Matrix Metalloproteinases
Interleukin-4
Interleukin-10
Strength of materials
Interleukin-6
Cytokines
Messenger RNA
polycaprolactone
Fibers

Keywords

  • Achilles tendinitis
  • Diclofenac
  • Fibrous sheet
  • Polycaprolactone
  • Tendon healing

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

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title = "Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis",
abstract = "We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.",
keywords = "Achilles tendinitis, Diclofenac, Fibrous sheet, Polycaprolactone, Tendon healing",
author = "Lee, {Tae Hoon} and Kim, {Sung Eun} and Lee, {Jae Yong} and Kim, {Jae Gyoon} and Kyeongsoon Park and Kim, {Hak Jun}",
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AU - Lee, Tae Hoon

AU - Kim, Sung Eun

AU - Lee, Jae Yong

AU - Kim, Jae Gyoon

AU - Park, Kyeongsoon

AU - Kim, Hak Jun

PY - 2019/1/1

Y1 - 2019/1/1

N2 - We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.

AB - We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.

KW - Achilles tendinitis

KW - Diclofenac

KW - Fibrous sheet

KW - Polycaprolactone

KW - Tendon healing

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