Abstract
We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.
| Original language | English |
|---|---|
| Journal | Journal of Industrial and Engineering Chemistry |
| DOIs | |
| Publication status | Accepted/In press - 2019 Jan 1 |
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Keywords
- Achilles tendinitis
- Diclofenac
- Fibrous sheet
- Polycaprolactone
- Tendon healing
ASJC Scopus subject areas
- Chemical Engineering(all)
Cite this
Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis. / Lee, Tae Hoon; Kim, Sung Eun; Lee, Jae Yong; Kim, Jae Gyoon; Park, Kyeongsoon; Kim, Hak Jun.
In: Journal of Industrial and Engineering Chemistry, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis
AU - Lee, Tae Hoon
AU - Kim, Sung Eun
AU - Lee, Jae Yong
AU - Kim, Jae Gyoon
AU - Park, Kyeongsoon
AU - Kim, Hak Jun
PY - 2019/1/1
Y1 - 2019/1/1
N2 - We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.
AB - We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.
KW - Achilles tendinitis
KW - Diclofenac
KW - Fibrous sheet
KW - Polycaprolactone
KW - Tendon healing
UR - http://www.scopus.com/inward/record.url?scp=85060753867&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060753867&partnerID=8YFLogxK
U2 - 10.1016/j.jiec.2019.01.018
DO - 10.1016/j.jiec.2019.01.018
M3 - Article
JO - Journal of Industrial and Engineering Chemistry
JF - Journal of Industrial and Engineering Chemistry
SN - 1226-086X
ER -