Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis

Tae Hoon Lee; Sung Eun Kim; Jae Yong Lee; Jae Gyoon Kim; Kyeongsoon Park; Hak Jun Kim

doi:10.1016/j.jiec.2019.01.018

Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis

Tae Hoon Lee, Sung Eun Kim, Jae Yong Lee, Jae Gyoon Kim, Kyeongsoon Park, Hak Jun Kim

Department of Orthopedic Surgery

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.

Original language	English
Pages (from-to)	152-161
Number of pages	10
Journal	Journal of Industrial and Engineering Chemistry
Volume	73
DOIs	https://doi.org/10.1016/j.jiec.2019.01.018
Publication status	Published - 2019 May 25

Keywords

Achilles tendinitis
Diclofenac
Fibrous sheet
Polycaprolactone
Tendon healing

ASJC Scopus subject areas

Chemical Engineering(all)

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Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis. / Lee, Tae Hoon; Kim, Sung Eun; Lee, Jae Yong; Kim, Jae Gyoon; Park, Kyeongsoon; Kim, Hak Jun.

In: Journal of Industrial and Engineering Chemistry, Vol. 73, 25.05.2019, p. 152-161.

Research output: Contribution to journal › Article › peer-review

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title = "Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis",

abstract = "We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.",

keywords = "Achilles tendinitis, Diclofenac, Fibrous sheet, Polycaprolactone, Tendon healing",

author = "Lee, {Tae Hoon} and Kim, {Sung Eun} and Lee, {Jae Yong} and Kim, {Jae Gyoon} and Kyeongsoon Park and Kim, {Hak Jun}",

note = "Funding Information: This study was supported by a grant from the Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea ( HI13C1501 ).",

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AU - Kim, Sung Eun

AU - Lee, Jae Yong

AU - Kim, Jae Gyoon

AU - Park, Kyeongsoon

AU - Kim, Hak Jun

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PY - 2019/5/25

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N2 - We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.

AB - We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.

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KW - Diclofenac

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