Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis

Tae Hoon Lee; Sung Eun Kim; Jae Yong Lee; Jae Gyoon Kim; Kyeongsoon Park; Hak Jun Kim

doi:10.1016/j.jiec.2019.01.018

Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis

Tae Hoon Lee, Sung Eun Kim, Jae Yong Lee, Jae Gyoon Kim, Kyeongsoon Park, Hak Jun Kim

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.

Original language	English
Pages (from-to)	152-161
Number of pages	10
Journal	Journal of Industrial and Engineering Chemistry
Volume	73
DOIs	https://doi.org/10.1016/j.jiec.2019.01.018
Publication status	Published - 2019 May 25

Keywords

Achilles tendinitis
Diclofenac
Fibrous sheet
Polycaprolactone
Tendon healing

ASJC Scopus subject areas

Chemical Engineering(all)

Access to Document

10.1016/j.jiec.2019.01.018

Cite this

Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis. / Lee, Tae Hoon; Kim, Sung Eun; Lee, Jae Yong; Kim, Jae Gyoon; Park, Kyeongsoon; Kim, Hak Jun.

In: Journal of Industrial and Engineering Chemistry, Vol. 73, 25.05.2019, p. 152-161.

Research output: Contribution to journal › Article › peer-review

@article{b75b488f9d9545d0a3f975da4392f46c,

title = "Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis",

abstract = "We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.",

keywords = "Achilles tendinitis, Diclofenac, Fibrous sheet, Polycaprolactone, Tendon healing",

author = "Lee, {Tae Hoon} and Kim, {Sung Eun} and Lee, {Jae Yong} and Kim, {Jae Gyoon} and Kyeongsoon Park and Kim, {Hak Jun}",

note = "Funding Information: This study was supported by a grant from the Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea ( HI13C1501 ). Publisher Copyright: {\textcopyright} 2019 The Korean Society of Industrial and Engineering Chemistry",

year = "2019",

month = may,

day = "25",

doi = "10.1016/j.jiec.2019.01.018",

language = "English",

volume = "73",

pages = "152--161",

journal = "Journal of Industrial and Engineering Chemistry",

issn = "1226-086X",

publisher = "Korean Society of Industrial Engineering Chemistry",

}

TY - JOUR

T1 - Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis

AU - Lee, Tae Hoon

AU - Kim, Sung Eun

AU - Lee, Jae Yong

AU - Kim, Jae Gyoon

AU - Park, Kyeongsoon

AU - Kim, Hak Jun

N1 - Funding Information: This study was supported by a grant from the Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea ( HI13C1501 ). Publisher Copyright: © 2019 The Korean Society of Industrial and Engineering Chemistry

PY - 2019/5/25

Y1 - 2019/5/25

N2 - We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.

AB - We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.

KW - Achilles tendinitis

KW - Diclofenac

KW - Fibrous sheet

KW - Polycaprolactone

KW - Tendon healing

UR - http://www.scopus.com/inward/record.url?scp=85060753867&partnerID=8YFLogxK

U2 - 10.1016/j.jiec.2019.01.018

DO - 10.1016/j.jiec.2019.01.018

M3 - Article

AN - SCOPUS:85060753867

VL - 73

SP - 152

EP - 161

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

SN - 1226-086X

ER -

Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this