Wrapping of tendon tissues with diclofenac-immobilized polycaprolactone fibrous sheet improves tendon healing in a rabbit model of collagenase-induced Achilles tendinitis

Tae Hoon Lee, Sung Eun Kim, Jae Yong Lee, Jae Gyoon Kim, Kyeongsoon Park, Hak Jun Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.

Original languageEnglish
JournalJournal of Industrial and Engineering Chemistry
DOIs
Publication statusAccepted/In press - 2019 Jan 1

    Fingerprint

Keywords

  • Achilles tendinitis
  • Diclofenac
  • Fibrous sheet
  • Polycaprolactone
  • Tendon healing

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this