X-ray scattering effect on the heterogeneous dose distribution in a cell box

Myonggeun Yoon, Jungwook Shin, Jungwon Kwak, Dongho Shin, Sung Yong Park, Se Byeong Lee, Doo Hyun Lee, Kyung Hwan Shin, Hong Ryull Pyo, Joo Young Kim, Kwan Ho Cho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The dose distribution in a cell box is very important factor for the radiobiology experiment since it affects the cell survival probabilities. When the x-ray is irradiated to the closed (or sealed) cell box, which is frequently used for the experiment of oxygen enhancement ratio (OER) research, it is possible that x-ray scattering effect by cell boxes may cause the inhomogeneous dose distribution within a cell box. In this study, we have investigated the inhomogeneity of the dose distribution with three different sizes of cubical cell boxes, whose side lengths are 10, 15 and 20 cm. The difference of the doses at the center of 10 cm box and 20 cm box was measured to be less than 2 % for both 6 MV and 15 MV x-ray irradiation. That indicates the absolute dose at the center of cell box doesn’t much depend on the size of cell box. Unlike the absolute dose value at the center of box, the relative dose distribution in a cell box has the strong dependency upon the condition of the cell box. The results show that the percentage showing more than 10 % dose difference to the average dose value goes up to ~ 40 %. Our experimental evidence suggests that when the closed box is used for the radiobiological experiment, the dose inhomogeneity within the cell box is not negligible and the location of the cells within a box should be carefully designed.

Original languageEnglish
Title of host publicationIFMBE Proceedings
PublisherSpringer Verlag
Pages2047-2050
Number of pages4
Volume14
Edition1
Publication statusPublished - 2007
Externally publishedYes
Event10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 - Seoul, Korea, Republic of
Duration: 2006 Aug 272006 Sep 1

Other

Other10th World Congress on Medical Physics and Biomedical Engineering, WC 2006
CountryKorea, Republic of
CitySeoul
Period06/8/2706/9/1

Keywords

  • Cell box
  • Homogeneity
  • OER
  • Radiobiology
  • Scattering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

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  • Cite this

    Yoon, M., Shin, J., Kwak, J., Shin, D., Park, S. Y., Lee, S. B., Lee, D. H., Shin, K. H., Pyo, H. R., Kim, J. Y., & Cho, K. H. (2007). X-ray scattering effect on the heterogeneous dose distribution in a cell box. In IFMBE Proceedings (1 ed., Vol. 14, pp. 2047-2050). Springer Verlag.