XPC polymorphisms and lung cancer risk

Ga Young Lee, Jin Sung Jang, Sin Yeob Lee, Hyo Sung Jeon, Kyung Mee Kim, Jin Eun Choi, Jung Min Park, Myung Hwa Chae, Won Kee Lee, Sin Kam, In-San Kim, Jae Tae Lee, Tae Hoon Jung, Jae Yong Park

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Polymorphisms in DNA repair genes may be associated with differences in the capacity to repair DNA damage and thereby influence an individual's susceptibility to smoking-related cancer. To test this hypothesis, we investigated the potential association of 7 XPC polymorphisms (-449G→C, -371G→A, -27G→C, Val499-Arg, PAT-/+, IVS11-5C→A and Lys939Gln) and their haplotypes with lung cancer risk in a Korean population. XPC genotypes were determined in 432 lung cancer patients and 432 healthy controls frequency-matched for age and sex. XPC haplotypes were predicted using a Bayesian algorithm in the Phase program. The combined -27CG+CC genotype was associated with a significantly increased risk for overall lung cancer compared to the -27GG genotype (adjusted OR = 1.97, 95% CI 1.22-3.17, p = 0.005). The other 6 polymorphisms were not significantly associated with overall risk of lung cancer. When lung cancer cases were categorized by tumor histology, the -371AA genotype was associated with a significantly increased risk of squamous cell carcinoma compared to the combined -371GG and GA genotype (adjusted OR = 2.08, 95% CI 1.09-4.00, p = 0.03). The PAT-/+, IVS11-5C→A and Lys939Gln polymorphisms were associated with a significantly decreased risk of small cell carcinoma (SM) under a dominant model for the polymorphic allele (adjusted OR = 0.49, 95% CI 0.29-0.82, p = 0.006; adjusted OR = 0.60, 95% CI 0.36-1.00, p = 0.05; and adjusted OR = 0.58, 95% CI 0.35-0.97, p = 0.04, respectively). Consistent with genotyping analyses, haplotype 4 (1112222) containing the PAT+/IVS11-5A/939Gln alleles was associated with a significantly decreased risk of SM (adjusted OR = 0.56, 95% CI 0.37-0.85, p = 0.007 and Bonferroni-corrected p = 0.049), whereas haplotype 5 (1122111) containing the -27C allele was associated with a significantly increased risk of SM (adjusted OR = 2.88, 95% CI 1.41-5.87, p = 0.004 and Bonferroni-corrected p = 0.028). These results suggest that XPC polymorphisms/haplotypes may contribute to genetic susceptibility for lung cancer.

Original languageEnglish
Pages (from-to)807-813
Number of pages7
JournalInternational Journal of Cancer
Volume115
Issue number5
DOIs
Publication statusPublished - 2005 Jul 10
Externally publishedYes

Fingerprint

Lung Neoplasms
Haplotypes
Genotype
Alleles
Small Cell Carcinoma
Genetic Predisposition to Disease
DNA Repair
DNA Damage
Squamous Cell Carcinoma
Neoplasms
Histology
Smoking
Population
Genes

Keywords

  • Genetic susceptibility
  • Haplotype
  • Lung cancer
  • Polymorphism
  • XPC

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lee, G. Y., Jang, J. S., Lee, S. Y., Jeon, H. S., Kim, K. M., Choi, J. E., ... Park, J. Y. (2005). XPC polymorphisms and lung cancer risk. International Journal of Cancer, 115(5), 807-813. https://doi.org/10.1002/ijc.20900

XPC polymorphisms and lung cancer risk. / Lee, Ga Young; Jang, Jin Sung; Lee, Sin Yeob; Jeon, Hyo Sung; Kim, Kyung Mee; Choi, Jin Eun; Park, Jung Min; Chae, Myung Hwa; Lee, Won Kee; Kam, Sin; Kim, In-San; Lee, Jae Tae; Jung, Tae Hoon; Park, Jae Yong.

In: International Journal of Cancer, Vol. 115, No. 5, 10.07.2005, p. 807-813.

Research output: Contribution to journalArticle

Lee, GY, Jang, JS, Lee, SY, Jeon, HS, Kim, KM, Choi, JE, Park, JM, Chae, MH, Lee, WK, Kam, S, Kim, I-S, Lee, JT, Jung, TH & Park, JY 2005, 'XPC polymorphisms and lung cancer risk', International Journal of Cancer, vol. 115, no. 5, pp. 807-813. https://doi.org/10.1002/ijc.20900
Lee GY, Jang JS, Lee SY, Jeon HS, Kim KM, Choi JE et al. XPC polymorphisms and lung cancer risk. International Journal of Cancer. 2005 Jul 10;115(5):807-813. https://doi.org/10.1002/ijc.20900
Lee, Ga Young ; Jang, Jin Sung ; Lee, Sin Yeob ; Jeon, Hyo Sung ; Kim, Kyung Mee ; Choi, Jin Eun ; Park, Jung Min ; Chae, Myung Hwa ; Lee, Won Kee ; Kam, Sin ; Kim, In-San ; Lee, Jae Tae ; Jung, Tae Hoon ; Park, Jae Yong. / XPC polymorphisms and lung cancer risk. In: International Journal of Cancer. 2005 ; Vol. 115, No. 5. pp. 807-813.
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N2 - Polymorphisms in DNA repair genes may be associated with differences in the capacity to repair DNA damage and thereby influence an individual's susceptibility to smoking-related cancer. To test this hypothesis, we investigated the potential association of 7 XPC polymorphisms (-449G→C, -371G→A, -27G→C, Val499-Arg, PAT-/+, IVS11-5C→A and Lys939Gln) and their haplotypes with lung cancer risk in a Korean population. XPC genotypes were determined in 432 lung cancer patients and 432 healthy controls frequency-matched for age and sex. XPC haplotypes were predicted using a Bayesian algorithm in the Phase program. The combined -27CG+CC genotype was associated with a significantly increased risk for overall lung cancer compared to the -27GG genotype (adjusted OR = 1.97, 95% CI 1.22-3.17, p = 0.005). The other 6 polymorphisms were not significantly associated with overall risk of lung cancer. When lung cancer cases were categorized by tumor histology, the -371AA genotype was associated with a significantly increased risk of squamous cell carcinoma compared to the combined -371GG and GA genotype (adjusted OR = 2.08, 95% CI 1.09-4.00, p = 0.03). The PAT-/+, IVS11-5C→A and Lys939Gln polymorphisms were associated with a significantly decreased risk of small cell carcinoma (SM) under a dominant model for the polymorphic allele (adjusted OR = 0.49, 95% CI 0.29-0.82, p = 0.006; adjusted OR = 0.60, 95% CI 0.36-1.00, p = 0.05; and adjusted OR = 0.58, 95% CI 0.35-0.97, p = 0.04, respectively). Consistent with genotyping analyses, haplotype 4 (1112222) containing the PAT+/IVS11-5A/939Gln alleles was associated with a significantly decreased risk of SM (adjusted OR = 0.56, 95% CI 0.37-0.85, p = 0.007 and Bonferroni-corrected p = 0.049), whereas haplotype 5 (1122111) containing the -27C allele was associated with a significantly increased risk of SM (adjusted OR = 2.88, 95% CI 1.41-5.87, p = 0.004 and Bonferroni-corrected p = 0.028). These results suggest that XPC polymorphisms/haplotypes may contribute to genetic susceptibility for lung cancer.

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