Xylodon flaviporus-Derived Drimane Sesquiterpenoids That Inhibit Osteoclast Differentiation

Jaeyoung Kwon; Hyaemin Lee; Seung Mok Ryu; Yeongseon Jang; Hak Cheol Kwon; Yuanqiang Guo; Jong Soon Kang; Jae Jin Kim; Dongho Lee

doi:10.1021/acs.jnatprod.9b00559

Xylodon flaviporus-Derived Drimane Sesquiterpenoids That Inhibit Osteoclast Differentiation

Jaeyoung Kwon, Hyaemin Lee, Seung Mok Ryu, Yeongseon Jang, Hak Cheol Kwon, Yuanqiang Guo, Jong Soon Kang, Jae Jin Kim, Dongho Lee

Research output: Contribution to journal › Article

Abstract

The presence of excessive osteoclasts is a major factor in skeletal diseases. The present study aimed to discover osteoclast differentiation inhibitors from the basidiomycete Xylodon flaviporus. Seven new drimane sesquiterpenoids (1-7) and 7-ketoisodrimenin-5-ene (8) were obtained and characterized by various spectroscopic methods. The isolated compounds were evaluated for their inhibitory effects against receptor activator of nuclear factor-kappa-B ligand-induced osteoclastogenesis in mouse bone marrow macrophages. Compounds 1, 3, and 6 showed potent activities with IC₅₀ values of 1.6, 0.9, and 2.1 μM, respectively, while 4, 5, and 7 exhibited relatively weak activities with IC₅₀ values of 10.7, 10.1, and 8.5 μM, respectively.

Original language	English
Pages (from-to)	2835-2841
Number of pages	7
Journal	Journal of Natural Products
Volume	82
Issue number	10
DOIs	https://doi.org/10.1021/acs.jnatprod.9b00559
Publication status	Published - 2019 Jan 1

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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Kwon, J., Lee, H., Ryu, S. M., Jang, Y., Kwon, H. C., Guo, Y., Kang, J. S., Kim, J. J., & Lee, D. (2019). Xylodon flaviporus-Derived Drimane Sesquiterpenoids That Inhibit Osteoclast Differentiation. Journal of Natural Products, 82(10), 2835-2841. https://doi.org/10.1021/acs.jnatprod.9b00559

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abstract = "The presence of excessive osteoclasts is a major factor in skeletal diseases. The present study aimed to discover osteoclast differentiation inhibitors from the basidiomycete Xylodon flaviporus. Seven new drimane sesquiterpenoids (1-7) and 7-ketoisodrimenin-5-ene (8) were obtained and characterized by various spectroscopic methods. The isolated compounds were evaluated for their inhibitory effects against receptor activator of nuclear factor-kappa-B ligand-induced osteoclastogenesis in mouse bone marrow macrophages. Compounds 1, 3, and 6 showed potent activities with IC50 values of 1.6, 0.9, and 2.1 μM, respectively, while 4, 5, and 7 exhibited relatively weak activities with IC50 values of 10.7, 10.1, and 8.5 μM, respectively.",

author = "Jaeyoung Kwon and Hyaemin Lee and Ryu, {Seung Mok} and Yeongseon Jang and Kwon, {Hak Cheol} and Yuanqiang Guo and Kang, {Jong Soon} and Kim, {Jae Jin} and Dongho Lee",

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AU - Kwon, Jaeyoung

AU - Lee, Hyaemin

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AU - Jang, Yeongseon

AU - Kwon, Hak Cheol

AU - Guo, Yuanqiang

AU - Kang, Jong Soon

AU - Kim, Jae Jin

AU - Lee, Dongho

PY - 2019/1/1

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AB - The presence of excessive osteoclasts is a major factor in skeletal diseases. The present study aimed to discover osteoclast differentiation inhibitors from the basidiomycete Xylodon flaviporus. Seven new drimane sesquiterpenoids (1-7) and 7-ketoisodrimenin-5-ene (8) were obtained and characterized by various spectroscopic methods. The isolated compounds were evaluated for their inhibitory effects against receptor activator of nuclear factor-kappa-B ligand-induced osteoclastogenesis in mouse bone marrow macrophages. Compounds 1, 3, and 6 showed potent activities with IC50 values of 1.6, 0.9, and 2.1 μM, respectively, while 4, 5, and 7 exhibited relatively weak activities with IC50 values of 10.7, 10.1, and 8.5 μM, respectively.

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