TY - JOUR
T1 - Xylodon flaviporus-Derived Drimane Sesquiterpenoids That Inhibit Osteoclast Differentiation
AU - Kwon, Jaeyoung
AU - Lee, Hyaemin
AU - Ryu, Seung Mok
AU - Jang, Yeongseon
AU - Kwon, Hak Cheol
AU - Guo, Yuanqiang
AU - Kang, Jong Soon
AU - Kim, Jae Jin
AU - Lee, Dongho
N1 - Funding Information:
This research was supported by the Korea Institute of Science & Technology Program (2E29561 and 2Z05620), the KRIBB Research Initiative Program, Korea Polar Research Institute (PE19100), and the National Research Foundation of Korea (NRF-2019R1A2C1006226 and NRF-2019R1A4A1020626).
PY - 2019/10/25
Y1 - 2019/10/25
N2 - The presence of excessive osteoclasts is a major factor in skeletal diseases. The present study aimed to discover osteoclast differentiation inhibitors from the basidiomycete Xylodon flaviporus. Seven new drimane sesquiterpenoids (1-7) and 7-ketoisodrimenin-5-ene (8) were obtained and characterized by various spectroscopic methods. The isolated compounds were evaluated for their inhibitory effects against receptor activator of nuclear factor-kappa-B ligand-induced osteoclastogenesis in mouse bone marrow macrophages. Compounds 1, 3, and 6 showed potent activities with IC50 values of 1.6, 0.9, and 2.1 μM, respectively, while 4, 5, and 7 exhibited relatively weak activities with IC50 values of 10.7, 10.1, and 8.5 μM, respectively.
AB - The presence of excessive osteoclasts is a major factor in skeletal diseases. The present study aimed to discover osteoclast differentiation inhibitors from the basidiomycete Xylodon flaviporus. Seven new drimane sesquiterpenoids (1-7) and 7-ketoisodrimenin-5-ene (8) were obtained and characterized by various spectroscopic methods. The isolated compounds were evaluated for their inhibitory effects against receptor activator of nuclear factor-kappa-B ligand-induced osteoclastogenesis in mouse bone marrow macrophages. Compounds 1, 3, and 6 showed potent activities with IC50 values of 1.6, 0.9, and 2.1 μM, respectively, while 4, 5, and 7 exhibited relatively weak activities with IC50 values of 10.7, 10.1, and 8.5 μM, respectively.
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U2 - 10.1021/acs.jnatprod.9b00559
DO - 10.1021/acs.jnatprod.9b00559
M3 - Article
C2 - 31599157
AN - SCOPUS:85073165364
VL - 82
SP - 2835
EP - 2841
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 10
ER -