Abstract
The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 Cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.
| Original language | English |
|---|---|
| Pages (from-to) | 231-234 |
| Number of pages | 4 |
| Journal | Experimental and Molecular Medicine |
| Volume | 32 |
| Issue number | 4 |
| Publication status | Published - 2000 Dec 31 |
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Keywords
- Idiopathic azoospermia
- Klinefelter syndrome
- Microdeletion
- Y chromosome
ASJC Scopus subject areas
- Biochemistry
- Genetics
Cite this
Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of klinefelter syndrome. / Lee, Yong Ho; Kim, Tak; Kim, Mee Hye; Kim, Young Tae; Kim, Sun Haeng.
In: Experimental and Molecular Medicine, Vol. 32, No. 4, 31.12.2000, p. 231-234.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of klinefelter syndrome
AU - Lee, Yong Ho
AU - Kim, Tak
AU - Kim, Mee Hye
AU - Kim, Young Tae
AU - Kim, Sun Haeng
PY - 2000/12/31
Y1 - 2000/12/31
N2 - The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 Cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.
AB - The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 Cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.
KW - Idiopathic azoospermia
KW - Klinefelter syndrome
KW - Microdeletion
KW - Y chromosome
UR - http://www.scopus.com/inward/record.url?scp=0034739830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034739830&partnerID=8YFLogxK
M3 - Article
C2 - 11190276
AN - SCOPUS:0034739830
VL - 32
SP - 231
EP - 234
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
SN - 1226-3613
IS - 4
ER -