Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of klinefelter syndrome

Yong Ho Lee, Tak Kim, Mee Hye Kim, Young Tae Kim, Sun Haeng Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 Cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalExperimental and Molecular Medicine
Volume32
Issue number4
Publication statusPublished - 2000 Dec 31

Keywords

  • Idiopathic azoospermia
  • Klinefelter syndrome
  • Microdeletion
  • Y chromosome

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Fingerprint Dive into the research topics of 'Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of klinefelter syndrome'. Together they form a unique fingerprint.

  • Cite this