Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of klinefelter syndrome

Yong Ho Lee, Tak Kim, Mee Hye Kim, Young Tae Kim, Sun Haeng Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 Cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalExperimental and Molecular Medicine
Volume32
Issue number4
Publication statusPublished - 2000 Dec 31

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Klinefelter Syndrome
Azoospermia
Chromosomes
Polymerase chain reaction
Defects
DNA
Polymerase Chain Reaction
Male sterility due to Y-chromosome deletions

Keywords

  • Idiopathic azoospermia
  • Klinefelter syndrome
  • Microdeletion
  • Y chromosome

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of klinefelter syndrome. / Lee, Yong Ho; Kim, Tak; Kim, Mee Hye; Kim, Young Tae; Kim, Sun Haeng.

In: Experimental and Molecular Medicine, Vol. 32, No. 4, 31.12.2000, p. 231-234.

Research output: Contribution to journalArticle

Lee, Yong Ho ; Kim, Tak ; Kim, Mee Hye ; Kim, Young Tae ; Kim, Sun Haeng. / Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of klinefelter syndrome. In: Experimental and Molecular Medicine. 2000 ; Vol. 32, No. 4. pp. 231-234.
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