Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of klinefelter syndrome

Yong Ho Lee; Tak Kim; Mee Hye Kim; Young Tae Kim; Sun Haeng Kim

doi:10.1038/emm.2000.38

Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of klinefelter syndrome

Yong Ho Lee, Tak Kim, Mee Hye Kim, Young Tae Kim, Sun Haeng Kim

Department of Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 Cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.

Original language	English
Pages (from-to)	231-234
Number of pages	4
Journal	Experimental and Molecular Medicine
Volume	32
Issue number	4
DOIs	https://doi.org/10.1038/emm.2000.38
Publication status	Published - 2000 Dec 31

Keywords

Idiopathic azoospermia
Klinefelter syndrome
Microdeletion
Y chromosome

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry

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abstract = "The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 Cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.",

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AU - Kim, Sun Haeng

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