Yeast (1 → 3)-(1 → 6)-β-D-glucan alleviates immunosuppression in gemcitabine-treated mice

Jin Sung Chae, Hocheol Shin, Youngju Song, Hee Kang, Chang Hwan Yeom, Sukchan Lee, Youn Seon Choi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Gemcitabine (2′-deoxy-2′,2′-difluorocytidine, dFdC) is one of the most effective chemotherapy drugs commonly used for treatment of various tumors. Despite its significant anticancer effects, some adverse effects create obstacles to treatment. The main toxicity of gemcitabine is myelosuppression, which not only reduces patient quality of life, but also hinders further anticancer treatment. In this respect, immunotherapy can address these drawbacks because of its ability to enhance the patient's immune system. To improve immune system function, yeast-derived β-glucans, which are well-known biologic response modifiers, were administered to gemcitabine-treated mice. The in vivo experiment revealed that orally administered yeast (1 → 3)-(1 → 6)-β-D-glucan effectively alleviated myelosuppression associated with gemcitabine-induced pancytopenia. Moreover, analysis of myelopoiesis-related cytokine expression through real-time PCR demonstrated that β-glucan treatment significantly upregulated hematopoietic responses in gemcitabine-treated mice. Furthermore, orally administered β-glucan significantly induced the expression of IFN-γ and IL-2 in splenocytes of gemcitabine-treated mice. It also restored the cytotoxicity of splenocytes against YAC-1 in gemcitabine-treated mice and displayed a positive effect on gemcitabine-damaged bone marrow tissue. In conclusion, yeast β-glucans have the potential to be used as adjuvants for alleviating chemotherapy-induced immunosuppression in patients.

Original languageEnglish
Pages (from-to)1169-1175
Number of pages7
JournalInternational Journal of Biological Macromolecules
Volume136
DOIs
Publication statusPublished - 2019 Sep 1

Keywords

  • Gemcitabine
  • Hematopoiesis
  • Immunosuppression
  • Insoluble yeast β-glucan

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • Energy(all)

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