Yeast hydrolysate induces longitudinal bone growth and growth hormone release in rats

Min Kim Jung, Seong Yeong Kim, Eun Young Jung, Song Hwan Bae, Hyung Joo Suh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This study investigated the growth promoting effects of yeast extract (YH) fed to Sprague-Dawley male rats (3 weeks old) for 4 weeks. The negative (N)-control and positive (P)-control groups were given a daily oral administration of saline and foremilk (1 g/kg of BW), respectively, and the YH-1 and YH-2 groups were given daily administrations of YH (0.5 and 1 g/kg of BW, respectively). After 4 weeks, the YH-1, YH-2 and P-control groups showed significant differences in the body weight gain compared with the N-control group ( p < 0.05). The YH-1 and YH-2 groups also had significantly different tibial bone growths (0.47 and 0.49 mm/day, respectively) and femur bone growths (0.52 and 0.53 mm/day, respectively) compared with the N-control group (0.37 mm/day of tibial growth and 0.42 mm/day of femur growth) (p < 0.05). The YH-1 and YH-2 groups had significantly different growth plate (proximal epiphysis) height increments (0.62 and 0.56 mm, respectively) compared with the N-control group (0.17 mm) (p < 0.05). Lastly, the YH-1 and YH-2 groups presented different growth hormone (GH) levels (1.77 and 2.10 ng/mL, respectively) than the N-control group (0.82 ng/mL) (p < 0.05). YH administration increased longitudinal bone growth and GH secretion in rats. Consequently, YH may offer an improved ability to treat GH deficiency-related disorders.

Original languageEnglish
Pages (from-to)731-736
Number of pages6
JournalPhytotherapy Research
Volume23
Issue number5
DOIs
Publication statusPublished - 2009 May

Keywords

  • Growth hormone
  • Longitudinal bone growth
  • Yeast hydrolysate

ASJC Scopus subject areas

  • Pharmacology

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