Zeatin supplement improves scopolamine-induced memory impairment in mice

Mi Jeong Kim, Soo Jung Choi, Seung Taik Lim, Hye Kyung Kim, Young Jun Kim, Ho Geun Yoon, Dong Hoon Shin

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In this study, our aim was to clarify the ameliorative effects of zeatin, a development hormone in plants. Zeatin mitigated cognitive deficits and showed AChE inhibition in scopolamine (Scop)-induced mice following 21 d of zeatin treatment. After administration of Scop for 30 min, each mouse performed Y-maze and step-down latency tasks as a check on immediate against cognitive function. The results showed that zeatin administration attenuated Scop-induced memory damage and decreased AChE activity in the mice. This suggests that zeatin might be useful for protecting cognitive dysfunction, as well as for reducing the activation of AChE in dementia.

Original languageEnglish
Pages (from-to)577-581
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume72
Issue number2
DOIs
Publication statusPublished - 2008

Keywords

  • Acetylcholinesterase
  • Alzheimer's disease
  • Cognitive function
  • Scopolamine
  • Zeatin [6-(4-hydroxy-3-methyl- trans-2-butenylamino) purine]

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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