Zigzag turning preference of freely crawling cells

Taeseokniel Da Yang, Jin Sung Park, Youngwoon Choi, Wonshik Choi, Tae Wook Ko, Kyoung Jin Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The coordinated motion of a cell is fundamental to many important biological processes such as development, wound healing, and phagocytosis. For eukaryotic cells, such as amoebae or animal cells, the cell motility is based on crawling and involves a complex set of internal biochemical events. A recent study reported very interesting crawling behavior of single cell amoeba: in the absence of an external cue, free amoebae move randomly with a noisy, yet, discernible sequence of 'run-and-turns' analogous to the 'run-and-tumbles' of swimming bacteria. Interestingly, amoeboid trajectories favor zigzag turns. In other words, the cells bias their crawling by making a turn in the opposite direction to a previous turn. This property enhances the long range directional persistence of the moving trajectories. This study proposes that such a zigzag crawling behavior can be a general property of any crawling cells by demonstrating that 1) microglia, which are the immune cells of the brain, and 2) a simple rule-based model cell, which incorporates the actual biochemistry and mechanics behind cell crawling, both exhibit similar type of crawling behavior. Almost all legged animals walk by alternating their feet. Similarly, all crawling cells appear to move forward by alternating the direction of their movement, even though the regularity and degree of zigzag preference vary from one type to the other.

Original languageEnglish
Article numbere20255
JournalPLoS One
Volume6
Issue number6
DOIs
Publication statusPublished - 2011 Jun 13

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Animals
Cells
Trajectories
Biochemistry
Brain
Bacteria
Mechanics
Amoeba
cells
trajectories
Biological Phenomena
Direction compound
neuroglia
Microglia
Eukaryotic Cells
tissue repair
phagocytosis
Phagocytosis
cell movement
mechanics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Zigzag turning preference of freely crawling cells. / Da Yang, Taeseokniel; Park, Jin Sung; Choi, Youngwoon; Choi, Wonshik; Ko, Tae Wook; Lee, Kyoung Jin.

In: PLoS One, Vol. 6, No. 6, e20255, 13.06.2011.

Research output: Contribution to journalArticle

Da Yang, Taeseokniel ; Park, Jin Sung ; Choi, Youngwoon ; Choi, Wonshik ; Ko, Tae Wook ; Lee, Kyoung Jin. / Zigzag turning preference of freely crawling cells. In: PLoS One. 2011 ; Vol. 6, No. 6.
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