Zinc insulin hexamer loaded alginate zinc hydrogel: Preparation, characterization and in vivo hypoglycemic ability

Haoran Cheng, Haishan Wu, Ting Guo, Hyun Jin Park, Jinglei Li

Research output: Contribution to journalArticlepeer-review

Abstract

Alginate zinc hydrogel loaded with zinc insulin hexamer was prepared and characterized for oral insulin administration. The hydrogel was fabricated by dripping zinc insulin hexamer into sodium alginate solution and followed by crosslinking by zinc chloride. SEM image reveals the zinc insulin hexamer was integrated into the matrix of hydrogel. Zinc insulin hexamer loaded hydrogel shows no obvious cytotoxicity to both HT29 and Caco-2 cells. The developed hydrogel retards the burst release of insulin in simulated gastric fluid but promotes the release when in simulated intestinal fluid. In the diabetic mice, zinc insulin hexamer loaded alginate hydrogel demonstrates significant and prolonged hypoglycemic effect.

Original languageEnglish
Pages (from-to)173-181
Number of pages9
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume179
DOIs
Publication statusPublished - 2022 Oct

Keywords

  • Control release
  • Hydrogel
  • Insulin
  • Maltodextrin
  • Sodium alginate

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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