ZnO nanorod biosensor for highly sensitive detection of specific protein binding

Jin Suk Kim, Won Il Park, Chul-Ho Lee, Gyu Chul Yi

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

We report on the fabrication of electrical biosensors based on functionalized ZnO nanorod surfaces with biotin for highly sensitive detection of biological molecules. Due to the clean interface and easy surface modification, the ZnO nanorod sensors can easily detect streptavidin binding down to a concentration of 25 nM, which is more sensitive than previously reported one-dimensional (ID) nanostructure electrical biosensors. In addition, the unique device structure with a micrometer-scale hole at the center of the ZnO nanorod's conducting channel reduces the leakage current from the aqueous solution, hence enhancing device sensitivity. Moreover, ZnO nanorod field-effect-transistor (FET) sensors may open up opportunities to create many other oxide nanorod electrical sensors for highly sensitive and selective real-time detection of a wide variety of biomolecules.

Original languageEnglish
Pages (from-to)1635-1639
Number of pages5
JournalJournal of the Korean Physical Society
Volume49
Issue number4
Publication statusPublished - 2006 Oct 1
Externally publishedYes

Fingerprint

bioinstrumentation
nanorods
proteins
sensors
biotin
micrometers
leakage
field effect transistors
aqueous solutions
conduction
fabrication
oxides
molecules

Keywords

  • Biosensor
  • Field effect transistor (FET)
  • Nanorod
  • ZnO

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

ZnO nanorod biosensor for highly sensitive detection of specific protein binding. / Kim, Jin Suk; Park, Won Il; Lee, Chul-Ho; Yi, Gyu Chul.

In: Journal of the Korean Physical Society, Vol. 49, No. 4, 01.10.2006, p. 1635-1639.

Research output: Contribution to journalArticle

Kim, Jin Suk ; Park, Won Il ; Lee, Chul-Ho ; Yi, Gyu Chul. / ZnO nanorod biosensor for highly sensitive detection of specific protein binding. In: Journal of the Korean Physical Society. 2006 ; Vol. 49, No. 4. pp. 1635-1639.
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