ZnO nanorod biosensor for highly sensitive detection of specific protein binding

Jin Suk Kim, Won Il Park, Chul Ho Lee, Gyu Chul Yi

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We report on the fabrication of electrical biosensors based on functionalized ZnO nanorod surfaces with biotin for highly sensitive detection of biological molecules. Due to the clean interface and easy surface modification, the ZnO nanorod sensors can easily detect streptavidin binding down to a concentration of 25 nM, which is more sensitive than previously reported one-dimensional (ID) nanostructure electrical biosensors. In addition, the unique device structure with a micrometer-scale hole at the center of the ZnO nanorod's conducting channel reduces the leakage current from the aqueous solution, hence enhancing device sensitivity. Moreover, ZnO nanorod field-effect-transistor (FET) sensors may open up opportunities to create many other oxide nanorod electrical sensors for highly sensitive and selective real-time detection of a wide variety of biomolecules.

Original languageEnglish
Pages (from-to)1635-1639
Number of pages5
JournalJournal of the Korean Physical Society
Volume49
Issue number4
Publication statusPublished - 2006 Oct 1

Keywords

  • Biosensor
  • Field effect transistor (FET)
  • Nanorod
  • ZnO

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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